An Asymptotic Analysis of the Logrank Test

Asymptotic expansions for the null distribution of the logrank statistic and its distribution under local proportional hazards alternatives are developed in the case of iid observations. The results, which are derived from the work of Gu (1992) and Taniguchi (1992), are easy to interpret, and provide some theoretical justification for many behavioral characteristics of the logrank test that have been previously observed in simulation studies. We focus primarily upon (i) the inadequacy of the usual normal approximation under treatment group imbalance; and, (ii) the effects of treatment group imbalance on power and sample size calculations. A simple transformation of the logrank statistic is also derived based on results in Konishi (1991) and is found to substantially improve the standard normal approximation to its distribution under the null hypothesis of no survival difference when there is treatment group imbalance. This revised version was published online in July 2006 with corrections to the Cover Date.     

基于时间序列的知识管理初探

探讨了连续时间分布下知识交接的实现途径,针对知识员工的流动引起的知识动荡,提出企业的"实习平台"能够维持组织知识总量、平滑,实现知识在时间序列下的共享.运用元认知模型修正企业的决策过程,使组织在实现创新能力不断提高的同时避免陷入思维固化,从而实现组织的知识创新能力在时间序列下的长远发展.     

盐酸多奈哌齐治疗血管性痴呆的临床疗效观察

目的观察盐酸多奈哌齐治疗血管性痴呆的疗效。方法102例血管性痴呆患者随机分为2组，治疗组51例，在常规治疗的基础上给予盐酸多奈哌齐5mg，每日1次；对照组54例，给予常规治疗，两组患者疗程均为12周，观察治疗前后认知功能（MMSE、HDS）及日常生活自理能力（ADL）的改善程度。结果治疗12周时，治疗组MMSE、HDS及ADL评分明显改善，较对照组有显著性差异（P〈0．05），自身对照结果显示，盐酸多奈哌齐治疗12周，治疗后MMSE、HDS及ADL评分较治疗前改善（P〈0．01），在治疗4周时，MMSE、HDS及ADL评分已有提高。结论盐酸多奈哌齐治疗血管性痴呆疗效确切，对患者认知功能及日常生活能力均为改善，无明显副作用，值得临床推广。     

诊所法律教育:我国法学实验教学的新领域

诊所法律教育是许多国家和地区所广泛采用的法律实践性教育模式.诊所法律教育在教学活动主体、教学内容等方面具有鲜明的特色.诊所法律教育在2000年被正式引入我国法律教育体系,并逐渐成为我国法学实验教学的重要领域之一.     

临床医学学科带头人胜任特征模型建构——量化与质化结合的方法

胜任特征模型研究是人力资源管理理论和实践的前沿问题,然而目前研究多采用单一的方法。本研究首先使用O*NET问卷对494位医院工作人员进行工作分析,然后对20位学科带头人进行行为事件访谈,结合进行专家小组访谈,构建临床医学学科带头人的胜任特征模型。研究发现多方法构建模型具有较好的效果。该职位胜任特征模型包括18项特征,可以分为个性特征,认知技能,管理能力三个理论层次。此外,本研究发现了个性化关怀等三项较新的素质要求。     

The Devil is in the Detail: Clinicians,Academics and Researchers Resolving the Problems of Clinical Research

The difficulties associated with conducting valid family therapy research within a clinical practice discourage many potential researchers. This article will describe collaboration between a group of academics, researchers and clinicians who decided to explore the process and efficacy of systemic family therapy conducted within a working private practice. The specific questions we are addressing are, whether the requests clients bring to their first session of therapy can be reliably classified by practitioners, whether these requests change over time, and whether the nature of the request is associated with therapist and client ratings of therapeutic outcome. Additional questions about the form and nature of the therapeutic alliance as experienced by both client and practitioner are also being explored. This paper will map the passage of the work from inception to its current state where over 140 clients are active participants. In doing so attention will be paid to the obstacles encountered: practical, financial and ethical, and the solutions devised to address these.     

并购绩效的经验研究方法

结合典型的并购经验研究的方法和结果,比较了并购绩效经验研究中经常使用的长期绩效研究法、事件研究法、诊断研究法和调查法等4种方法各自的含义与特点,同时考察了国外及国内并购经验研究对4种方法的运用情况,提出了在我国目前条件下适宜的研究方法的建议。     

Placing Clinical Social Workers “Between a Legal Rock and a Practice Hard Place”: Reactions to Madden and Parody

The debate about the veracity of incest memories uncovered in therapy is often impassioned and acrimonious. Recent statements by various professional organizations, advising that corroboration of recovered memories is the only method for determining their accuracy, have not decreased the intensity of this debate. This response to Madden and Parody's paper discusses the importance of corroboration of recovered memories of sexual abuse and details the clinical, scientific, and legal foundations for this approach. A point of confusion in Madden and Parody's paper and an important aspect of this response is the difference between clients who uncover completely new memories of childhood sexual abuse and clients who enter therapy with a history of sexual abuse. Those clients with new memories are the focus of this debate and the standard of care proposed in this paper.     

提高高等医学院校临床教学质量的若干思考

提高医学院校的临床教学质量应做好四个方面的工作:提高认识、增强教学意识,调动临床教学工作的积极性;加强临床教师队伍的建设,注重提高临床教学效果;加强临床教学管理规范化制度化建设;深化临床教学改革。     

构建医学生口腔临床技能和实践能力培养新模式

目的:建立培养学生口腔临床技能和实际工作能力的教学模式。方法:组成以训练临床综合技能为主的临床口腔医学课程群;开展一、二年级以接触社会、接触患者为主的社会实践;三、四年级以仿真头模操作为主的综合实验训练和口腔专业课学习兴趣小组;五年级以毕业实习为主的综合临床技能培养的教学模式。结果:提高了学生口腔临床技能和实际工作能力,患者对实习医生的满意率明显提高,学生的研究生录取率明显提高,毕业生当年就业率达100%,用人单位满意。结论:建立新型的教学模式是培养学生口腔临床技能和实际工作能力的可行方法。